While spreadsheets have carved out their place in the data toolkit, they easily become cumbersome and challenging to deal with when working on large datasets.Enter: Dataiku. It's a great tool for doing much of what you do in Excel (like cleaning, preparing, and analyzing data), except on larger, more complex datasets.
This reminds me of a recent story about some of the challenges that folks are running into, using MS Excel when the data sets get bigger.
Here is a link to a fun video about those challenges in particular.
I do like using DSS to get beyond these challenges.